Dieter O Fürst Selected Research

Filamins

6/2021	FLNC-Associated Myofibrillar Myopathy: New Clinical, Functional, and Proteomic Data.
1/2021	The p.Ala2430Val mutation in filamin C causes a "hypertrophic myofibrillar cardiomyopathy".
1/2020	Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation.
12/2015	Myofibrillar instability exacerbated by acute exercise in filaminopathy.
3/2013	Impairment of protein degradation in myofibrillar myopathy caused by FLNC/filamin C mutations.
1/2013	Filamin C-related myopathies: pathology and mechanisms.
1/2013	A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients.
9/2012	Pathophysiology of protein aggregation and extended phenotyping in filaminopathy.
6/2011	Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy.
12/2010	Dominant-negative effects of a novel mutation in the filamin myopathy.

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Dieter O Fürst Research Topics

Disease

16	Muscular Diseases (Myopathy) 01/2022 - 08/2005
13	Myofibrillar Myopathy 06/2021 - 08/2005
8	Cardiomyopathies (Cardiomyopathy) 11/2021 - 07/2006
5	Muscle Weakness 01/2022 - 10/2010
4	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019 - 07/2014
4	Fibrosis (Cirrhosis) 01/2019 - 10/2012
4	Distal Myopathies (Distal Muscular Dystrophy) 01/2013 - 03/2003
3	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 07/2015 - 03/2003
3	Pathological Protein Aggregation 03/2013 - 06/2006
2	Portal Hypertension 01/2019 - 09/2015
2	Hypertrophy 01/2017 - 12/2007
2	Neoplasms (Cancer) 01/2015 - 01/2011
2	Epidermolysa bullosa simplex and limb girdle muscular dystrophy 10/2002 - 06/2002
1	Heart Diseases (Heart Disease) 01/2017
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2017
1	Inclusion Body Myositis 01/2017
1	Myotilinopathy 01/2017
1	Tuberous Sclerosis (Bourneville's Disease) 01/2017
1	Limb-girdle muscular dystrophy type 2A 01/2017
1	Ventricular Tachycardia 10/2016
1	Myosin Storage Myopathy 07/2015
1	Sarcoma (Soft Tissue Sarcoma) 01/2015
1	Disease Progression 03/2013
1	Wounds and Injuries (Trauma) 01/2012
1	Infections 01/2012
1	Infarction (Infarctions) 03/2011
1	Inflammation (Inflammations) 03/2011
1	Neoplasm Metastasis (Metastasis) 01/2011
1	Melanoma (Melanoma, Malignant) 01/2011
1	Paralysis (Palsy) 10/2010
1	Cardiomegaly (Heart Hypertrophy) 03/2010
1	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2003
1	Autosomal Recessive Epidermolysis Bullosa Simplex 06/2002
1	Mitochondrial Diseases (Mitochondrial Disease) 06/2002
1	Muscular Dystrophies (Muscular Dystrophy) 06/2002

Drug/Important Bio-Agent (IBA)

23	Proteins (Proteins, Gene)FDA Link 06/2021 - 01/2003
16	FilaminsIBA 06/2021 - 01/2003
6	Protein AggregatesIBA 01/2021 - 01/2013
5	DesminIBA 01/2021 - 06/2002
3	ActininIBA 09/2010 - 01/2003
2	Amino Acids FDA Link 11/2021 - 01/2020
2	rho-Associated KinasesIBA 01/2019 - 07/2014
2	Myosins (Myosin)IBA 01/2017 - 07/2015
2	Atorvastatin (Lipitor)FDA Link 09/2015 - 10/2012
2	Thioacetamide (Thioacetamid)IBA 01/2015 - 07/2014
2	Nonsense Codon (Nonsense Mutation)IBA 01/2013 - 08/2005
2	cysteine and glycine-rich protein 3IBA 08/2004 - 03/2003
2	PlectinIBA 10/2002 - 06/2002
1	DysferlinIBA 01/2022
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2022
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2019
1	Human Serum Albumin FDA LinkGeneric 01/2019
1	Peptides (Polypeptides)IBA 01/2019
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2017
1	CalcineurinIBA 01/2017
1	Crystallins (Crystallin)IBA 01/2017
1	Molecular Chaperones (Chaperone, Molecular)IBA 01/2017
1	Adenosine Triphosphate (ATP)IBA 01/2017
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2017
1	Valosin Containing ProteinIBA 01/2017
1	Proline (L-Proline)FDA Link 01/2017
1	ConnectinIBA 01/2017
1	Connexin 43 (Connexin43)IBA 10/2016
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2015
1	Protein Kinase CIBA 01/2015
1	Monomeric GTP-Binding ProteinsIBA 01/2015
1	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2015
1	tyrosine receptor (receptor, tyrosine)IBA 01/2015
1	Angiotensin IIIBA 07/2014
1	Type 1 Angiotensin ReceptorIBA 07/2014
1	Janus Kinase 2IBA 07/2014
1	Biomarkers (Surrogate Marker)IBA 12/2013
1	Small Interfering RNA (siRNA)IBA 01/2012
1	multidrug resistance-associated protein 1IBA 03/2011
1	Leukotriene C4IBA 03/2011
1	P-SelectinIBA 01/2011
1	Fibronectins (Fibronectin)IBA 01/2011
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2011
1	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 01/2011
1	Liposomes (Liposome)IBA 01/2011
1	Integrin alpha4beta1 (VLA-4)IBA 01/2011
1	DNA (Deoxyribonucleic Acid)IBA 10/2010
1	Protein Isoforms (Isoforms)IBA 03/2010
1	F-actin-binding proteinsIBA 03/2010
1	EnzymesIBA 12/2007
1	Adenine FDA LinkGeneric 03/2003

Therapy/Procedure

2	Ligation 01/2015 - 07/2014
2	Lasers (Laser) 01/2013 - 01/2012
1	Liver Transplantation 01/2015
1	Therapeutics 07/2014